Psoriasis as intestinal disease - theory

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Newsletter is intended for doctors, experts and researchers. Reviews of the scientific publications devoted to pathogenesis of psoriatic disease will be regularly delivered. First of all in what certain models of pathogenesis (psoriasis and-or psoriatic arthritis) are offered. Newsletter archives

 

Mikhail Yuryevich Peslyak,
Nikolay Gavrilovich Korotky.
Metagenomes of blood and psoriatic skin. Research project. e2.2 edition,
M.: Antipsoriatic Association
"The Natural Alternative", 2019. - 67 pages.
ISBN 978-5-905504-06-8

Electronic Publication Date of edition e2.2: 2019, May 7.
DOI: 10.5281/zenodo.2667680

Main supplements:

A. Presentation and illustrations.
(e2.2, DOI: 10.5281/zenodo.2668376)

B. Supplements S1-S8.
(e2.2, DOI: 10.5281/zenodo.2668459)

The first stage of NCS-project devoted to the study, diagnostics and treatment of psoriasis is substantiated and given a detailed description. The purpose of the first stage is testing the basic hypotheses of new systemic YN-model of psoriasis pathogenesis. The test consists in complex studying of whole blood metagenome and metagenome of psoriatic skin (phagocytes). Metagenome is all non-host DNA (here - non-human) which is found in biomaterial. The necessary algorithms for complex studying of metagenomes are suggested and substantiated.
Survey and analytical assessment of the results of fundamental works on studying metagenomes of blood and skin is carried out. All works (published prior to the beginning of 2019) on determining bacterial DNA concentration in whole blood of healthy people are reviewed.
Detailed comparison of characteristics of 16S-test and WMS-test is carried out.
The objectives and tasks (including the order of solving them) of the first stage are formulated. The main questions are raised, to which the results of the first stage are supposed to give answers. The order of preparing and implementing WMS-test of whole blood is suggested.
Detailed comparison of YN-model of pathogenesis with the previously published Y-model is conducted. An analytical review of works on studying the attraction of blood neutrophils in psoriatic skin and their possible subsequent netosis is made. Netosis in psoriatic skin of neutrophils which are carriers of endocytosed Y-antigen in blood is qualified as an essential link in the vicious cycle of psoriatic inflammation within YN-model. Classification of psoriatic disease as netopathy is suggested.
Psoriagenic bacteria are given definition based on the existence of genes responsible for the formation of interpeptide bridges. The smallest peptides (peptidoglycan fragments) - potential Y-antigens are identified.

Illustrations are made as a presentation and can be found in Supplement A.
 

Mikhail Peslyak, Antipsoriatic Association "The Natural Alternative"
Nikolay Korotky, Pirogov Russian National Research Medical University

NCS-project of scientific research
"Development of new methods of complex diagnostics of metagenomes and microbiomes of throat, intestine, blood and skin of psoriatic patients, and also their corrections for achievement of long and steady remission".
Moscow, 2018
(NCS_summary)

NCS-Pitch
(v1.2, 10 pages, pdf)

DOI: 10.5281/zenodo.1472953

NCS-Presentation (and illustrations for pitch)
(v1.1, 31 slides, pdf)


DOI: 10.5281/zenodo.1473780

 

Presentation (project)

Psoriasis as skin reaction to systemic psoriatic process SPP.
Y-model of pathogenesis.
(version e2.1, 2012, Jun 17)

Download this presentation
(pdf-format)

Slides contain links to connected sections of e-books.
Put pdf-files of presentation and e-books in one directory that these links were functional
(othervise Adobe Reader, either does not find file, or opens the first page).
------


Date of first publication in Internet
version e2.0:
2012, May 2
(stored in archive of previous versions)

 


Mikhail Peslyak
Model of pathogenesis of psoriasis.
Part 1. Systemic psoriatic process.
MYPE, 2012. - 84 p.
ISBN 978-5-905504-02-0
English edition e4.0 (revised and updated),
Electronic Publication Date: 2012, Apr 14
Download this e-book free (pdf-format)

Date of first publication in Internet e2.0: 2009, Dec 30 (stored in archive of previous editions)

This e-book
on Scribd
(read and download free)

This e-book
on Arxiv.org
(download free)

Abstracts to Part 1 and Part 2.
Y-model of pathogenesis of psoriasis.
The summary scheme of dependencies.

Mikhail Peslyak
Model of pathogenesis of psoriasis.
Part 2. Local processes.

MYPE, 2012. - 110 p.
ISBN 978-5-905504-04-4
English edition e1.3,
Electronic Publication Date: 2012, Apr 14
Download this e-book free (pdf-format)

Date of first publication in Internet e1.2: 2011, Dec 28 (stored in archive of previous editions)

This e-book
on Scribd
(read and download free)

This e-book
on Arxiv.org
(download free)

Reviews from experts about the monograph
"Model of pathogenesis of psoriasis".



June 27 - July 1, 2012,
in Stockholm, Sweden was
3rd WORLD PSORIASIS & PSORIATIC ARTHRITIS CONFERENCE 2012


Next report (P025) was presented
on this conference:
Small intestine microflora at psoriasis. Its possible role in pathogenesis.
(Mikhail Peslyak,
Natalia Gumayunova, Alex Nesterov, Natalia Potaturkina-Nesterova)
This report and supplements are here.

Download all files
in one RAR-archive
(copy of free CD)



Topic "Psoriasis"
Viewing free.  For joining it is necessary to be registered.
 

Psoriasis as a consequence of incorporation of β-streptococci
into the microbiocenosis of highly permeable intestines (a pathogenic concept)
Vestn Dermatol Venerol 2005; 1: 9-18

 

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