Psoriasis as a consequence of incorporation of beta-streptococci into the microbiocenosis of highly permeable intestines (a pathogenic concept)
Korotkii NG (Korotky NG)
(Russian state medical university, Moscow)
Peslyak MY
(Holding "Kudits-obraz", Moscow, this web site)
A review of recent investigations into pathogenesis of psoriasis summarizing data on the relationship between the presence β-streptococci in the organism and the cutaneous immune reaction. Results of the studies on gastrointestinal pathology in psoriatic patients are presented. The authors propose a hypothesis that advocates the primary origin of psoriatic gastrointestinal pathology and secondary nature of skin manifestations. A chronic plaque psoriasis model is developed on the basis of the assumption on the key role of two psorafactors, i.e. hyperpermeability of intestinal walls for certain proteins and incorporation of beta-streptococci in the microbiocenosis of intestinal mucosa. The validity of the model is confirmed by the results of practical clinical work.
Vestn Dermatol Venerol 2005; 1: 9-18
ISSN 0042-4609
Journal NLM Unique ID: 0414246
Model of pathogenesis of psoriasis. Interaction of factors.
BS is beta-streptococcuses, BSP-antigens are beta-Streptococci Proteins - the
streptococcal cellular and membranous proteins being products of
disintegration BS.
This
study for the first time is published in Russian in the Internet -
Nov 24, 2003.
This study is published in
"Bulletin of dermatology and venerology"
(2005,1 :9-18) in Russian.
Download this study in English (with
the additions made while translating), July 7, 2005
(PDF-format).
The first time is published in the Internet - July 18, 2005.