Special oral administration method
Hydrogen ion activity (pH): a measure of the activity of hydrogen ions in a solution (pH = power of hydrogen ).
A pH range of 6.8 to 7.2 is considered neutral (distilled water has pH of 7).
pH < 6.8 is acidic (the lower pH, the higher the acidity).
pH > 7.2 is alkaline (the higher pH, the higher the alkalinity).
Acidity (normal) :
– in the lumen of the stomach on an empty stomach 1.5–2.0 pH.
– in the duodenal bulb 5.6–7.9 pH.
– in the jejunum and ileum neutral or slightly alkaline 7–8 pH.
– in the blood 7.36–7.44 pH.
The acidity level in the stomach is unfavorable for phages.
A significant percentage of phages are destroyed during passage through the stomach.
In order to:
– ensure that a higher percentage of phages remain intact when passing through the stomach;
– distribute a portion of the phages throughout the small intestine;
– ensure that a higher percentage of phages enter the bacterial biofilm during absorption;
It is recommended to:
a) Take the phages 1.5-2 hours before meals.
b) First, drink 100 ml of a 3% baking soda solution (3 g = 0.5 level teaspoon per 100 ml of water). Its pH is 8.3.
(It is more convenient to prepare the soda solution for two doses at once: 6 g = 1 level teaspoon per 200 ml of water).
In this case, pH in the stomach temporarily (for 75 minutes) increases by 3 units. The carbon dioxide formed during neutralization causes belching and some bloating.
This recommendation is only in the Instructions for Intesti-bacteriophage , although it is also true for all other phages.
If you have chronically elevated stomach acidity and/or are significantly overweight (large or obese people typically have larger stomachs), you should increase the volume of baking soda solution you drink. By how much? If it’s just a weight issue, then increase it proportionally to your excess weight over 70 kg (i.e., if you weigh 105 kg, for example, you should drink 150 ml of 3% baking soda solution). If chronically elevated stomach acidity is the issue, consult a gastroenterologist about the optimal volume of 3% baking soda solution.
c) Five to 10 minutes after drinking the soda solution (by this point, the active neutralization phase in the stomach is typically complete, accompanied by the release of carbon dioxide, slight bloating, and belching), take a serving of phages. Then, take large sips of clean water (600-800 ml) (recommended pH from 7 to 8 ). The water should be at a comfortable temperature, as it should be consumed within 15-30 minutes (the sooner, the better).
Distilled water has pH of 7, but the acceptable pH range for drinking water according is 6 to 9. It’s a good idea to purchase litmus paper (indicator paper) in strips or on a roll to accurately determine pH of water (and other liquids) you plan to drink during your treatment. Most of these should have pH above 7.
If you have access to alkaline mineral water (pH 7.2 to 8.5), it’s best to use it. It’s recommended to decarbonate the mineral water before drinking (leave the bottle open for several hours).
Acidic mineral waters have pH of 3.5-6.8, neutral waters have pH of 6.8-7.2, and alkaline waters have pH of 7.2-8.5 and higher.