Aliorum medicus ipse ulceribus scates
Personal experience of treatment in 2012-13.
Prehistory
I do have psoriasis since age of 8. From age of 16 years I’ve managed to keep it in moderate condition thanks to dietetics and cleansing methods. As now I’m 58, the experience of conscious struggle against psoriasis is more than 40 years… Since 1996 I observe certain diets: New ration (1996-1999), Ration 2000 (rus) (2000-2005), Ration 2006 (from 2006 to now). Constant observance of diets and periodic 3-5 day unloading courses, including cleansing of intestine, provided low level of psoriasis. PASI no more than 10, the area of lesion no more than 10%, maximum in winter-spring time. From the middle of 2001 I conduct photo documenting, in 2002 published Photo report (rus) on influence of following (non-following) of John Pagano regimen on psoriasis.
In 2005 the article in Vestnik of Dermatology and Venerology has been published “Psoriasis as a consequence of incorporation of beta-streptococci into the microbiocenosis of highly permeable intestines (a pathogenic concept)”
Within the next several years (2006-2010) there was work conducted on the monograph “Model of pathogenesis of psoriasis”, which first editions have been published in Russian (part 1 – in 2010, part 2 – in 2011), and then in English (both parts in 2011-12).
In 2009 series of works of group of researchers under the direction of professor Natalia Potaturkina-Nesterova (rus) has been published. For the first time in the world scientists of Ulyanovsk State University investigated small intestine microflora at patients with psoriasis. This data has entailed necessity of processing of the monograph, which last edition (in Russian and English) published in April, 2012.
….
Since 2010 I deliberately postponed such (as it was lead in Ulyanovsk) own SIBO (Small Intestinal Bacterial Overgrowth) test.
The reason is simple – I did not want the knowledge of my special case affected the concept formulated in the monograph.
Earlier I repeatedly received the information about my intestine microflora only on the basis of Gas Chromatography – Mass Spectrometry (GC-MS) blood analysis and (once) by small intestine biopsy. GC-MS research does not allow to define sensitivity of any microflora to antibiotics or bacteriophages. Therefore the subsequent courses of treatment did not contain them. I also twice (with interval of several years) was checked on small intestine permeability by ovalbumin-test. Both times have shown essential (in comparison with norm) increase of permeability.
…..
In the end of April 2012 also it became known that at the International conference in Stockholm it is necessary to give the report based on the first part of monograph and works of researchers from Ulyanovsk.
For this reason in the beginning of May 2012 I have decided to learn all the same how much my small intestine microflora is deviated from norm and whether it is deviated in general. About it some of especially attentive participants of dermatological conference could possibly ask (but have not asked – because of carelessness or politeness).
And well, of course, I hoped that if significant deviations will be found in my small intestine microflora it will be clear with what factors to struggle further.
After a week of active Internet and phone searches in Moscow I have found hospital in which they have agreed to do classical SIBO test. Namely gastroscopy (is more exact Esophagogastroduodenoscopy) ) with aspirate (and biopsy) capture in zone of ligament of Treitz (conditional border between Duodenum and Jejunum). Really both aspirate and biopsy captured on distance of 10 sm after ligament of Treitz. The capture of biomaterials immediately in duodenum before ligament of Treitz is quite admissible. Then the aspirate and biopsy were investigated by Microbial culturing in laboratory. For pathogenic bacteria (which were found out) sensitivity check to antibiotics and bacteriophages was lead. I.e. I went through the same examination which has been also executed for 121 patients with psoriasis during researches in Ulyanovsk plus in addition capture and biopsy crops has been carried.
And so – it was found out in me SIBO II degree (see section 4). And with appreciable including of beta-streptococci Str.agalatiae – 10Е4 CFU/ml, bacteria from among what I named psoragenic :-). Additional tests have shown that these Str.agalatiae are sensitive to one of bacteriophages, besides sensitivity to certain antibiotics
One of the hypotheses those offered in the monograph “Model of pathogenesis of psoriasis”
IB-Y – interpeptide bridges of peptidoglycan Str.pyogenes:
L-Ala(2-3) or L-Ala-L-Ser;
PG-Y – peptidoglycan containing interpeptide bridges IB-Y;
PsB – psoragenic bacteria, which have peptidoglycan PG-Y.
Circumstances have developed so that I have lead course of treatment (see section 5) only in September 2012. Before the beginning of course PASI was nearby 5-6. It was a consequence of two weeks at the sea resort. However experience shows that such decrease reached thanks to solar-sea baths would last for maximum of 1-3 months. And for these 1-3 months PASI inevitably would grow to preholiday level or even still above.So it was tens of times – in all years when I used the climatotherapy blessings. So it was always, but not this time!
Today, when I’m writing these lines, April 2013. Right after the course of treatment there has come a surprisingly deep and steady remission, so even “duty” plaques on elbows and knees almost completely passed. There were some pigmental spots and very small number of psoriatic dots. Such deep remission in my life had place only once (more than 30 years ago) – after I have excluded milk products from my ration.
It was natural to be checked up again on SIBO that I and did in the end of January 2013. The result was as expected (see section 4) – SIBO is not present (TBC < 10E3, and diagnosis SIBO is when TBC >= 10E5). Though in quantity less than 10E3, in biopsy were found beta-streptococci of other group, those showing sensitivity to the same bacteriophage. For this reason in the near future I assume to repeat course of treatment to try to tire out psoriasis into the invisible condition…
TBC = total bacterial count = total quantity of microorganisms which have been found out in 1 ml of biomaterial.